Staying in their lanes: Polarized migration keeps gut form and function aligned.

Postnatal development of the intestinal epithelium depends on planar cell polarity to coordinate epithelial migration, aligning tissue architecture with physiological function zones.

• Why it matters: The work addresses how developing gut tissue keeps structural organization and physiological roles synchronized, rather than drifting out of alignment during epithelial remodeling.
• What they did: Lee et al. report in Developmental Cell that planar cell polarity is required to coordinate epithelial migration during postnatal intestinal epithelial development.
• The result: Planar cell polarity–linked migration alignment shapes tissue architecture, which in turn organizes zones of physiological function in the developing gut.

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