Lysosomal metabolism is essential for pancreatic ductal adenocarcinoma survival, with pathways supporting tumor growth and immune evasion despite limited success of current therapies.
Genes & Development
Cold Spring Harbor Laboratory Press · Genomics & Bioinformatics · ISSN 0890-9369, 1549-5477
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Human PIF1 primarily functions as a DNA translocase that clears secondary DNA structures by coupling unwinding with rapid rewinding, with only modest net unwinding observed.
Nuclear type I myosins are essential for maintaining nuclear structure and function, with depletion causing genome disorganization and nucleolar disruption.
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Multimerization of ELAV in Drosophila is crucial for neuronal gene regulation, with mutants unable to multimerize leading to embryonic lethality.
Nuclear type I myosins are essential for maintaining nuclear structure and function, with depletion causing genome disorganization and nucleolar disruption.
Lysosomal metabolism is essential for pancreatic ductal adenocarcinoma survival, with pathways supporting tumor growth and immune evasion despite limited success of current therapies.
Human PIF1 primarily functions as a DNA translocase that clears secondary DNA structures by coupling unwinding with rapid rewinding, with only modest net unwinding observed.
Mute represses histone mRNA accumulation outside S phase by antagonizing Mxc phosphorylation, revealing a novel cell cycle-dependent regulation mechanism for histone genes.
Honeybadger micropeptide encoded by PVT1 suppresses RAS-MAPK signaling, and its loss enhances MYC-driven tumor progression in MYC+ cancers.
Drosophila Mute differentially regulates cell cycle-dependent and independent histone mRNA expression, affecting 801 genes and causing developmental defects.
Temporal gating of mRNA biogenesis controls stress-induced transcript export, with early transcripts exported before global export inhibition during human cell stress.
Disruption of 5'ETS processing in rRNA leads to significant changes in nucleolar structure and nuclear organization, highlighting its role in maintaining cellular architecture.
MEIOSIN independently activates meiotic genes across vertebrates, including species lacking STRA8, highlighting a conserved core mechanism in meiosis.
Cancer-associated adipocytes (CAAs) supply fatty acids to tumor cells, promoting cancer progression through metabolic cross-talk in the tumor microenvironment.
Firefox, a protein encoded by circular PVT1, is crucial for MYC-driven cancer growth, with its depletion reducing tumor progression in models.
Loss of p53 in mouse embryonic stem cells triggers immediate germline programs, chromatin changes, and metabolic shifts within 48 hours.
Scm self-assembles into PcG bodies to recruit PRC2.1, enabling rapid formation of H3K27me3 domains during Polycomb silencing in Drosophila.
Maternally methylated Mest gDMR regulates Klf14 imprinting through allele-specific TAD restructuring in mice and humans.
The hnRNPA1 D262V mutation causes mitochondrial dysfunction and translation stalling in ALS-affected cells, revealing a key link to neuronal death.
Cardiac lymphatics regulate embryonic heart growth through Reelin-mediated epicardial signaling, influencing organ size by controlling Wt1 and Igf1 pathways.
Regulatory circuits linking immune cells, metabolism, and stroma sustain noninfectious granulomas across diverse diseases, maintaining persistent tissue aggregates without pathogens.
Sharp cell type boundaries in hair follicle development arise from coordinated Wnt and Hedgehog signaling, producing a precise boundary from a continuous morphogen gradient.
A conserved regulatory helix in HUWE1 controls ASCL1 degradation via its phospho-degron in small cell lung cancer, revealing a new autoinhibitory mechanism.
MutLα enhances methylpurine DNA glycosylase activity, increasing alkylation damage cytotoxicity and revealing new targets for overcoming chemoresistance in tumors.
MYC proteins enhance tumor cell resilience by engaging in multiple complexes and binding DNA and RNA, supporting oncogenic gene expression in cancer.
MCM10 and RECQL4 cooperatively and redundantly activate the CMG helicase during human DNA replication initiation, with severe defects observed when both are depleted.
Wnt/β-catenin cues are decoded into binary fate decisions in C. elegans through ZIP-7/DBP-mediated transcriptional regulation, enabling embryo-wide patterning.
Disruptions in 3D genome architecture, driven by intrinsic and architectural factors, actively contribute to cancer progression, with structural alterations reshaping oncogenic programs.
Identification of novel germ granule proteins reveals their essential roles in RNAi and small RNA inheritance in Caenorhabditis elegans, with PINT-1 being crucial for siRNA biogenesis.
Maternal small RNAs regulate hybrid compatibility in plants and animals, with incompatibilities affecting 100% of hybrid cases through distinct mechanisms.
A conserved Notch-Meis1-Pbx1 cascade directs secretory progenitors to become spatially diverse best4 (+) cells in vertebrate intestines.
Overexpression of neuronal bet-1 in Caenorhabditis elegans extends lifespan by activating systemic stress responses through cell-nonautonomous signaling.
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Moving areas, week to 3 Oct 2026
- Single-cell and spatial transcriptomics10
- Artificial Intelligence in Healthcare and Education8
- CAR-T cell therapy research7
- Neuroinflammation and Neurodegeneration Mechanisms6
- Lung Cancer Treatments and Mutations5
- Diabetes Treatment and Management4
- Pancreatic and Hepatic Oncology Research4
- Photosynthetic Processes and Mechanisms4
- Genomics and Chromatin Dynamics4
- Gut microbiota and health4