Architectural logic of the 3D genome: mechanisms of dysregulation and emerging cancer therapeutics.

Disruptions in 3D genome architecture, driven by intrinsic and architectural factors, actively contribute to cancer progression, with structural alterations reshaping oncogenic programs.

• Why it matters: Understanding whether 3D genome organization causes or reflects functional changes is crucial for developing targeted cancer therapies and improving disease intervention strategies.
• What they did: The study evaluates the causal relationship between genome structure and function using a framework that distinguishes intrinsic chromatin features from architectural factors, incorporating evidence from cancer-related alterations and recent AI/ML advances.
• The result: Findings suggest that structural genome disruptions can actively influence oncogenic processes, and AI/ML approaches enable prediction of 3D genome organization, advancing potential therapeutic applications.