Fat cadherin cleavage releases a nuclear fragment to regulate gene transcription.

Cleaved FtICD generates a nuclear fragment that enters nuclei in vivo and regulates transcription, with two conserved nuclear localization signals enabling nuclear import.

• Why it matters: Ft cadherins are known to control growth, planar cell polarity, and metabolism, but how FtICD influences gene expression was unclear.
• What they did: The study mapped nuclear localization signals on FtICD, showed membrane-bound FtICD is cleaved and imported into nuclei in vivo, and used endogenous ChIP-seq plus ectopic FtICD expression to identify Ft-associated targets.
• The result: FtICD suppresses wing growth, alters PCP, and changes expression of many genes, forming a complex with Scalloped and Yorkie and showing Ft ChIP-seq peak co-localization with Hippo effectors.

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