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A TerminaTOR of mTORC1 signaling.

Nature Chemical Biology · 1 Nov 2026 · Journal Article

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Genetically targeted mTORC1 inhibitor reveals transcriptional control by nuclear mTORC1.
Nature Chemical Biology · 1 Nov 2026 · Journal Article
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Targeting TerminaTOR to the nucleus specifically inhibits nuclear mTORC1 and reveals that nuclear mTORC1 regulates transcription of CCAAT motif-containing genes.
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https://jclub.com.au/a/42135521
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De novo lipogenesis controls antigen presentation and metastatic immune escape in triple-negative breast cancer.
bioRxiv · 28 Oct 2026 · Preprint
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Disrupting fatty acid synthase (FASN)-driven de novo lipogenesis in triple-negative breast cancer suppresses metastasis and increases tumor-cell MHC-I antigen presentation and CD8+ T cell activation.
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https://jclub.com.au/a/10.64898/2026.05.21.726063
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A GCN1-independent activator of the kinase GCN2.
eLife · 27 Oct 2026 · Journal Article
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Three structurally distinct low-micromolar GCN2 activators were identified in an in cellulo chemical screen, including one that activates GCN2 independently of GCN1.
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https://jclub.com.au/a/42945303
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