Giredestrant combined with everolimus significantly extends progression-free survival in ER-positive, HER2-negative advanced breast cancer, especially in ESR1-mutated tumors, with a median of 10 months versus 5.5 months.
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PI3K/AKT/mTOR signaling in cancer
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Loss of Lsp2 reduces TOP mRNA translation via 4E-BP, extending Drosophila lifespan independently of rapamycin, highlighting a new longevity pathway.
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Loss of TSC2 in neural progenitors causes cell-autonomous formation of reactive astrocytes with neurodegenerative features in tuberous sclerosis.
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Inhibition of Rag GTPases and mTORC1 in enterocytes increases intestinal stem cell activity via distinct pathways, with Rag GTPases affecting Mitf and mTORC1 acting independently.
Loss of eIF4G2 accelerates pancreatic cancer progression, metastasis, and basal-like tumor features, highlighting its role as a critical translational checkpoint.
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