Deletion of SPI1 in microglia worsens amyloid pathology by reducing microglial response and phagocytosis in Alzheimer's disease models.
- Open access
- 5 cites
Neuron
Cell Press · Neuroscience · ISSN 0896-6273, 1097-4199
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Imagining scenes and speech activates transmodal association networks more than sensory-specific areas, highlighting their role in self-generated mental imagery.
- 3 cites
Meningeal macrophages refine dorsal meningeal lymphatic development, influencing social behavior and potentially contributing to autism spectrum disorder.
- Open access
- 3 cites
Cortical and brainstem circuits, especially the ventrolateral periaqueductal gray, causally mediate multimodal placebo analgesia in mice, with lasting effects after injury.
- Open access
- 7 cites
Reg-EXTL3 axis promotes nerve-cancer interactions in pancreatic ductal adenocarcinoma, with silencing reducing tumor progression and pain in mice.
- 3 cites
Latest in Neuron
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Lateral hypothalamic neurons independently modulate striatal dopamine, creating a spatially organized dopamine landscape during consumption in mice.
Standardized biobanks of animal model tissues and biofluids could transform preclinical research by enhancing reproducibility and reducing animal use.
Disruptions in neurotransmitter systems across multiple scales cause circuit instability that underpins psychotic symptoms in diverse disorders.
A TMEM119-tankyrase axis limits microglial phagocytosis, with its disruption causing excessive synapse elimination and memory destabilization in adult mice.
Activation of P2Y2 purinergic receptors restores endothelial function and behavior in a mouse model of autism with a 16p11.2 deletion.
SCN2A deficiency impairs cortico-striatal circuitry in human brain assembloids, reducing synaptic connectivity despite increased neuronal excitability, with a 50% reduction in cortical projections.
Cervical lymphadenectomy causes significant impairment of brain lymphatic clearance, leading to metabolic stress and synaptic protein disruptions associated with cognitive decline.
OpenFISH achieves simultaneous, cell-type-aware mapping of transcripts and metabolites within the same tissue section, revealing metabolic heterogeneity and zonation in the CNS.
An African ancestry-enriched H1 sub-haplotype at 17q21.31 reveals distinct tau regulation and challenges existing MAPT haplotype classification.
Guidelines for accurate time-resolved spectral parameterization improve analysis of neural oscillations and aperiodic activity at fine timescales.
Exponentiated gradient learning produces synaptic weight distributions that closely resemble brain-like log-normal patterns and maintains synaptic sign stability.
Microglia-derived SPP1 and ITGB1 signaling sustain thalamic hyperexcitability and chronic post-stroke pain in mice.
Blocking peripheral CXCR3 reduces T cell infiltration and neurodegeneration in a mouse model of tauopathy, with a 50% decrease in T cell accumulation.
Distinct subpopulations of Grpr+ neurons in the dorsal horn mediate specific itch and pain responses, with Tac1-expressing neurons required for chemical itch and mechanical hypersensitivity.
A direct BLA to DLS projection modulates stimulus-evoked grooming behavior and is strengthened in compulsive mice, revealing limbic influence on sensorimotor circuits.
Hippocampal representations of alternative spatial possibilities are dynamically modulated to support adaptive decision-making, with distinct patterns linked to changing values and future choices.
Lef1-positive hypothalamic neurons and Kcnk2 modulation coordinate metabolic responses to cold, with Lef1 activation mimicking cold-induced thermogenesis and feeding.
Activation of anterior zona incerta GABAergic neurons projecting to the ventral tegmental area drives compulsive binge eating in a mouse model, with increased neuronal excitability linked to the behavior.
A miR-10a-5p-γCaMKII axis mediates peripheral signals that increase brain vulnerability during female midlife, with miR-10a-5p levels rising significantly in this period.
NFIs act as conserved global temporal regulators of radial glial progenitor development, with mutations causing bidirectional impairments linked to human neocortical malformations.
Understanding the "recipe" for intelligence reveals many parallels between natural and artificial systems, advancing both neuroscience and AI development.
- Open access
Post-inhibitory rebound firing of mPOA neurons, driven by T-type Ca2+ currents, is essential for hypothalamic activation during male mating in mice.
Dense calcium imaging reveals that specific neuron clusters in the mouse LPBN encode distinct interoceptive signals during food intake, with activity patterns mirroring gastrointestinal movement.
Extracellular GPNMB promotes alpha-synuclein uptake in Parkinson's disease models, with higher GPNMB expression linked to more widespread pathology in humans.
Adult intracranial arteries supply Ntn4, a neurovascular factor critical for maintaining specific sympathetic neurons, with Ntn4 decline linked to neuronal loss in mice.
- Open access
Sympathetic signaling via ADRA1B in hepatic stellate cells promotes liver fibrosis by enabling immune evasion, with a positive correlation between axon density and fibrosis severity.
A global dopaminergic learning rate in the nucleus accumbens core enables mice to adaptively forage across six options within minutes.
- Open access
- 6 cites
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