Blocking cholinergic interneurons in the nucleus accumbens prevents opioid-reward learning without affecting dopamine signaling, revealing a key cholinergic gate.
Neurotransmitter Receptor Influence on Behavior
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Latest in Neurotransmitter Receptor Influence on Behavior
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Reduced serotonin neuron activity in the dorsal raphe during pregnancy drives food-craving-like behavior in mice, with SK3 ion channels playing a key role.
Selective activation of 5-HT(2A) receptors over 5-HT(2B) receptors was achieved with derivatives showing high specificity, confirmed by cryo-EM structures.
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Locus coeruleus noradrenaline neurons exhibit topographic organization linked to distinct brain regions and functions in mice.
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Cerebellar input streams encode dopamine rewards with both predictive and instructive signals, influencing motivated behavior in mice.
ASt neurons encode sustained threat cues and are essential for defensive behaviors, with Drd2+ neurons necessary for cue-conditioned fear responses.
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Nearly all long-range octopaminergic and tyraminergic neurons in Drosophila melanogaster brain are now accessible with new transgenic driver strains, enabling detailed circuit analysis.
Glutamate concentration at mouse interneuron synapses dynamically regulates AMPA receptor conductance states, affecting key biophysical properties like rectification and Ca2+ permeability.
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