JAMA Psychiatry

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Across the World Mental Health International College Student initiative, 37% to 58% of first-year students worldwide meet 12-month DSM-5 disorder criteria, alongside low treatment use and major academic impairment.

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Clinician care remains essential for patients with severe mental illness as AI is integrated into psychiatry, and replacing it risks undermining standards of practice.

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Youth-caregiver diagnostic discordance for multiple psychiatric diagnoses is examined longitudinally across developmental stages in the Adolescent Brain Cognitive Development (ABCD) cohort.

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Mobile delivery of integrated PrEP and medication for opioid use disorder on a unit did not improve 26-week confirmed PrEP or MOUD use versus peer navigation alone.

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AI-based prediction and stratification models should be judged by trustworthiness, transportability, and usefulness at the point of care, not hype.

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The Modernizing Opioid Treatment Access Act could change how methadone for opioid use disorder is dispensed under US regulations if passed.

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In postmortem human dorsal claustrum, schizophrenia is linked to 1717 differentially expressed genes, with 1149 (66.9%) upregulated in schizophrenia versus unaffected comparisons.

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ACE protein levels are significantly lower in cerebrospinal fluid and serum of 122 early-stage psychosis patients versus 78 healthy controls, with Cohen d down to -1.16.

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Clinicians are urged to consider whether artificial intelligence models may induce delusionlike beliefs, and to address this potential phenomenon.

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A cross-sectional study evaluated a multilayer perceptron model to estimate delay discounting among college-aged adults.

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Early-career investigators’ preliminary work is highlighted to showcase emerging talent in psychiatric research and provide support during a challenging period for science.

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Partner similarity for psychiatric disorders is substantial in a nationwide Danish cohort, with parental correlations reaching r=0.38 for schizophrenia and r=0.11 for anorexia.

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From 2012–2022 in Danish registry data, prediagnostic risk profiles for ADHD and ASD attenuated toward controls, with low birth weight OR dropping from 1.54 to 1.17.

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Glutamatergic drugs for schizophrenia are linked to renewed reasons for revisiting their utility, motivating updated treatment goals for the condition.

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Genomic testing for psychiatric prevention is not supported for population-wide screening, but targeted use—especially early in treatment—may improve diagnosis timing and monitoring.

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Placental growth factor trajectories across pregnancy trimesters differ in women whose children later received an ADHD diagnosis, indicating trimester-specific variation linked to later ADHD status.

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In adults with serious mental illness, initiating GLP-1 receptor agonists was linked to lower 4-year all-cause mortality than initiating SGLT2 inhibitors (4.91% vs 6.45%; HR 0.76).

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Developing clinical competence for psychiatric care of deaf and hard-of-hearing patients hinges on careful diagnostic consideration and cultural humility.

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UMBRAA (unidentifiable multidrug blinding with reduced, authorized awareness) is proposed as a strategy to address masking challenges in psychedelic trials.

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In 369 female participants with bulimia nervosa, ENIGMA meta-analysis linked diagnosis to smaller nucleus accumbens volume (d=-0.20) and reduced superior/transverse temporal surface area (d≈-0.24 to -0.26).

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Removing ultraprocessed foods from the diets of patients with major depressive disorder is assessed for feasibility and acceptability in a pilot crossover trial.

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Evidence from low- and middle-income countries, viewed through India, challenges prevailing assumptions about suicide pathways, prevention, and surveillance, and highlights how evidence shapes global policy.

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Elevated reward-expectancy–linked activation in left ventrolateral prefrontal cortex and pre-supplementary motor area is positively associated with mania or hypomania risk in adults at risk.

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In 2023, 18.1 million people globally were living with anorexia nervosa or bulimia nervosa, generating 3.83 million DALYs, with most cases among females and ages 10–24.