The abstract is read at the publisher; the summary is JClub's.
Mobile delivery of integrated PrEP and medication for opioid use disorder on a unit did not improve 26-week confirmed PrEP or MOUD use versus peer navigation alone.
- Why it matters: Integrated HIV prevention and opioid use disorder treatment models are needed for people who inject drugs, but it was unclear whether mobile delivery could improve uptake beyond existing community navigation.
- What they did: In a 2-group open-label randomized clinical trial (May 2021–September 2024) in Houston, Los Angeles, New York, Philadelphia, and Washington, DC, 409 participants were assigned to mobile integrated services (n=203) or peer navigation to community services (n=206) for 26 weeks.
- The result: At 26 weeks, confirmed PrEP use was 5.4% vs 2.9% and MOUD use was 14.8% vs 10.7%, with similar results at 52 weeks; HIV incidence was 0.9 per 100 person-years, and all-cause mortality was lower in the intervention arm (HR 0.29; P=.03).
The findingWhy it mattersWhat they didThe result
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