Research area · week to 3 Oct 2026

Alzheimer's disease research and treatments

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Arc mediates intercellular tau transmission via extracellular vesicles.
Cell · 23 July 2026 · Journal Article
Arc is essential for packaging tau into extracellular vesicles, significantly facilitating intercellular tau transmission in neuronal systems.
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https://jclub.com.au/a/42372723
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Progressive remodeling of global protein interaction networks in a mouse model of tauopathy.
Cell Reports · 1 Oct 2026 · Journal Article
Protein interaction networks in a mouse tauopathy model undergo significant, phosphorylation-dependent remodeling, with over 20 key complexes showing dynamic changes during disease progression.
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https://jclub.com.au/a/42826098
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Disease-specific tau polymorphs are associated with unique protein networks across proteinopathies.
EMBO Journal · 1 Oct 2026 · Journal Article
Distinct tau polymorphs in Alzheimer’s, PSP, and DLB associate with unique protein networks, with 493 high-confidence interactors revealing disease-specific patterns.
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https://jclub.com.au/a/42613429
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Prion-like transmission of human tau strains in the mouse brain.
Nature · 30 Sept 2026 · Journal Article
Tau filaments from human Alzheimer's and corticobasal degeneration brains propagate in mice, maintaining their distinct structures and supporting prion-like transmission.
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https://jclub.com.au/a/42816607
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Leveraging structurally-informed bioorthogonal conjugation for alpha synuclein fibril surveillance
bioRxiv · 30 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.12.675751
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Tau hyperphosphorylation impairs cooperative binding to microtubules and perturbs organelle trafficking in neurons.
eLife · 28 Sept 2026 · Journal Article
Hyperphosphorylated tau disrupts microtubule envelopes and impairs lysosome transport, contributing to neurodegeneration in tauopathies like Alzheimer's disease.
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https://jclub.com.au/a/42804373
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Mitochondria remodel near synapses to boost metabolic capacity and fuel plasticity
bioRxiv · 26 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.08.27.672715
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Patterns of modifiable lifestyle, behavioural and health-related risk factors and their associations with incident dementia in UK Biobank
medRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.24.26363838
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Single molecule detection of Tau seeds in extracellular vesicles from Alzheimer's disease brains
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.21.753085
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State-selective inhibition of alpha-synuclein aggregation by de novo oligomer-binding proteins
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.07.13.738012
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APOA1 links a late fetal epithelial program to colonic maturation and injury responses
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.24.754040
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Profiling of Aggregated Amyloid β42-induced Proteomic Alterations in KOLF2.1J Induced Pluripotent Stem Cell-derived Neurons
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.20.753014
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Effects of Soybean-derived Phosphatidylserine on Working Memory and Motor Speed in Healthy Adults with Subjective Memory Complaints: A 12-Week Randomized, Placebo-Controlled Trial
medRxiv · 24 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.18.26363447
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AI-based characterization of Alzheimer's disease phenotypes from population-scale single-cell data.
Nature Medicine · 23 Sept 2026 · Journal Article
AI-based analysis of over 6 million nuclei reveals specific cell subpopulations linked to diverse Alzheimer's disease phenotypes.
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https://jclub.com.au/a/42778763
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Ceperognastat in Alzheimer Disease: Lessons From a Negative Clinical Trial.
JAMA · 22 Sept 2026 · Comment
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https://jclub.com.au/a/42441398
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Ceperognastat in Early Symptomatic Alzheimer Disease: A Randomized Clinical Trial.
JAMA · 22 Sept 2026 · Randomized Controlled Trial
Ceperognastat failed to significantly slow disease progression in early symptomatic Alzheimer disease at 100 weeks, despite reducing brain volume loss.
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https://jclub.com.au/a/42441396
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Ceperognastat in Early Symptomatic Alzheimer Disease: Research Summary.
JAMA · 22 Sept 2026 · Journal Article
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https://jclub.com.au/a/42441387
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Elevated phosphorylated α-synuclein and phosphorylated tau in Lrrk2 p.G2019S-mutant mice following influenza A pneumonitis
bioRxiv · 19 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.07.31.667659
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A miR-10a-5p-γCaMKII axis links periphery-to-brain signaling to cognitive vulnerability during female midlife.
Neuron · 18 Sept 2026 · Journal Article
A miR-10a-5p-γCaMKII axis mediates peripheral signals that increase brain vulnerability during female midlife, with miR-10a-5p levels rising significantly in this period.
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https://jclub.com.au/a/42759510
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Population-scale burden analysis of rare damaging coding variants identifies novel risk genes for Alzheimer's disease and related dementias and Parkinson's disease and related disorders
medRxiv · 18 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.03.26347540
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Decline in mitochondrial health and lysosomal acidification in human neurons during normal aging
bioRxiv · 17 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.09.717473
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A Molecularly Anchored Spatial Transcriptomic Framework for Precise CA1-Subiculum Parcellation and Region-Resolved Analysis in Alzheimer's Disease.
GigaScience · 17 Sept 2026 · Journal Article
A molecularly anchored spatial transcriptomic framework accurately delineates CA1 and Subiculum regions, revealing distinct molecular features and transition zones in the human hippocampus.
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https://jclub.com.au/a/42752570
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Predicting Risk of Cognitive Impairment With Alzheimer Disease Blood Biomarkers.
JAMA · 15 Sept 2026 · Comment
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https://jclub.com.au/a/42449502
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Prognostic Value of Blood-Based P-Tau217 Levels for Progression to Cognitive Impairment.
JAMA · 15 Sept 2026 · Journal Article
Elevated blood-based p-tau217 levels predict up to 38% risk of cognitive impairment over 10 years in unimpaired older adults.
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https://jclub.com.au/a/42449500
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APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers's disease.
Nature Genetics · 14 Sept 2026 · Journal Article
APOE-stratified GWAS reveal novel genetic signals for Alzheimer's disease, with DDHD1 showing protective effects specifically in APOE ε4 carriers.
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https://jclub.com.au/a/42736378
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A proteome-wide biochemical screen defines binding determinants of the core autophagy protein LC3B
bioRxiv · 10 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.01.05.697675
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Polyanionic peptibody ameliorates tau pathology and promotes neuronal proteostasis in a tau transgenic mouse model
bioRxiv · 9 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.08.13.665777
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Analysis of the off-target interaction of amyloid PET tracers with human brain sulfotransferases
bioRxiv · 9 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.16.732640
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The hidden role of the bone marrow in Alzheimer's disease.
Nature Neuroscience · 8 Sept 2026 · Journal Article
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https://jclub.com.au/a/42711431
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mTOR drives cerebrovascular dysfunction and blood-brain barrier breakdown in a model of Alzheimers disease with cerebral amyloid angiopathy
bioRxiv · 7 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.23.733858
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Mathematical Modeling of Late-Stage LC Aggregation and Cardiac Injury Following Establishment of a Pathogenic Plasma-Cell Clone
bioRxiv · 6 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.30.685705
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