bioRxiv · 7 Sept 2026 · Preprint · Open access

Reactive oxygen species alter dopaminergic and purinergic signaling and microglia physiology in the nucleus accumbens

Wadsworth, Webb + 13 more

Open access

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Lysosomal dysfunction drives a transcriptional and epigenetic signature found in disease-associated microglia in neurodegenerative diseases.
Immunity · 11 Aug 2026 · Journal Article
Lysosomal dysfunction causes microglia-specific epigenetic and transcriptional changes linked to neurodegenerative diseases, with a significant impact observed in Sgsh-deficient mice.
- 2 cites
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Deletion of SPI1 in microglia exacerbates amyloid pathology by impairing microglial response in Alzheimer's disease models.
Neuron · 5 Aug 2026 · Journal Article
Deletion of SPI1 in microglia worsens amyloid pathology by reducing microglial response and phagocytosis in Alzheimer's disease models.
- Open access
- 5 cites
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Microglia and neuroinflammation: function, heterogeneity, and crosstalk.
Cellular & molecular immunology · 1 July 2026 · Review
Microglia exhibit diverse activation states and cellular subpopulations, enabling dual neuroprotective or neurotoxic roles in neuroinflammatory conditions.
- Open access
- 14 cites
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