bioRxiv · 11 Sept 2026 · Preprint · Open access

Maternal high-fat diet drives sex-specific microglia remodeling of serotonergic reward circuitry

Bilbo, Patton + 9 more

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Lysosomal dysfunction drives a transcriptional and epigenetic signature found in disease-associated microglia in neurodegenerative diseases.
Immunity · 11 Aug 2026 · Journal Article
Lysosomal dysfunction causes microglia-specific epigenetic and transcriptional changes linked to neurodegenerative diseases, with a significant impact observed in Sgsh-deficient mice.
- 2 cites
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Deletion of SPI1 in microglia exacerbates amyloid pathology by impairing microglial response in Alzheimer's disease models.
Neuron · 5 Aug 2026 · Journal Article
Deletion of SPI1 in microglia worsens amyloid pathology by reducing microglial response and phagocytosis in Alzheimer's disease models.
- Open access
- 5 cites
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Microglia and neuroinflammation: function, heterogeneity, and crosstalk.
Cellular & molecular immunology · 1 July 2026 · Review
Microglia exhibit diverse activation states and cellular subpopulations, enabling dual neuroprotective or neurotoxic roles in neuroinflammatory conditions.
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- 14 cites
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