Nature Methods
Nature Portfolio · Genomics & Bioinformatics · ISSN 1548-7091, 1548-7105
- Impact (2-yr)
- 22.8
- h-index
- 522
- Open access
- 38%
- Works
- 8.5K
- Papers this month
- 17
Rebuilt
Moved this week
Latest in Nat Methods
Newest first · last 60 days
A two-step machine learning approach enables transferable prediction of small-molecule retention times across different chromatographic conditions, outperforming existing methods.
- Open access
CytoVI enables comprehensive analysis of antibody-based single-cell data, accurately modeling 350 proteins and revealing disease-related immune cell states.
- Open access
Graphene reservoirs enable precise, reproducible control of ice thickness in cryo-EM, achieving uniformity over large areas and improving imaging quality.
Spatial Hi-C reveals high-fidelity 3D chromatin structures in mammalian brain tissues at near-single-cell resolution.
ResolVI improves spatial transcriptomics analysis by probabilistically correcting molecule misassignments, batch effects, and nuisance factors, enhancing cell state discrimination and spatial expression detection.
Solid-state nanopores are poised to become essential tools for studying complex biological and synthetic macromolecular structures, surpassing their current role in sequencing.
NanoTS achieves over 0.980 F1 score in SNP detection from nanopore transcriptome data, significantly improving accuracy for both RNA and cDNA sequencing.
- Open access
SVPG achieves over tenfold faster pangenome graph augmentation and superior structural variant detection across multiple sequencing technologies.
Confinement force microscopy reveals two-phase cellular responses to dynamic spatial confinement, with a 2-fold increase in traction forces during active stress buildup.
- Open access
SPLENDID improves polygenic risk prediction accuracy across diverse populations by modeling genetic ancestry as a continuum without requiring ancestry labels, outperforming existing methods.
An engineered biliverdin-binding domain enables an ultralow-background, red-light-responsive optogenetic system with over 1,200-fold activation in mammalian cells.
WILD, a lightweight wireless platform with real-time closed-loop capabilities, enables long-term multimodal neural and behavioral recordings in freely moving mice.
MemBrain v2 achieves highly accurate, generalizable membrane segmentation, particle localization, and quantitative analysis in cryo-electron tomography with minimal manual effort.
- Open access
- 178 cites
Transferable signaling response signatures enable high-resolution reconstruction of in vivo cell signaling histories across diverse cell types.
- Open access
DeepWonder3D achieves high-fidelity 3D neuronal extraction from large-scale calcium imaging datasets, reducing computational costs tenfold and processing tens of thousands of neurons in hours.
AI-driven proteomics advances enable comprehensive protein identification and the creation of AI virtual cells, transforming the field with significant innovations.
Single-cell resolution spatial isoform sequencing reveals cell-type-specific isoform variability in multiple brain cell types, with over 450 million barcodes analyzed.
- Open access
Iterative Mapping reveals over 130 distinct tau proteoforms with up to six phosphorylation sites at the single-molecule level, surpassing traditional methods in sensitivity and resolution.
- Open access
- 1 cites
Spatial-ATAC-Hi-C uncovers distinct 3D genome architecture and gene regulation in mammalian tissues, revealing tumor heterogeneity and oncogenic events in human brain cancers.
kpiCells, a biomimetic platform, can measure piconewton-scale forces and replicate cellular states, advancing the study of immune cell mechanoregulation with high functional complexity.
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Journals this month
- bioRxiv5569
- medRxiv1738
- Environ Res483
- PNAS463
- Sci Adv439
- JAMA255
- Cell Rep210
- BMJ199
- Nat Commun177
- Environ Pollution170
- Lancet149
- Science138
- NEJM119
- Applied & Environ Microbio116
- J Exp Bot115
- Curr Biol112
- mBio109
- Nature104
Moving areas, week to 3 Oct 2026
- Single-cell and spatial transcriptomics10
- Artificial Intelligence in Healthcare and Education8
- CAR-T cell therapy research7
- Neuroinflammation and Neurodegeneration Mechanisms6
- Lung Cancer Treatments and Mutations5
- Diabetes Treatment and Management4
- Pancreatic and Hepatic Oncology Research4
- Photosynthetic Processes and Mechanisms4
- Genomics and Chromatin Dynamics4
- Gut microbiota and health4