The abstract is read at the publisher; the summary is JClub's.
PANGEA remaps human disease multicellular responses using 12.6 million cells, enabling systematic profiling across 160 diseases and 48 organs with a 32-cell-type, 165-subtype hierarchy.
- Why it matters: Disease biology spans many cell types, yet the coordinated multicellular response landscape across human tissues is not well mapped, limiting cross-tissue comparisons and interpretation.
- What they did: The team built PANGEA from an automated pipeline processing raw sequence data from public repositories, then annotated cells with 32 major types and 165 subtypes across a 46.5 million–cell atlas spanning 160 diseases.
- The result: The atlas reveals core disease archetypes across organs and functions as a reference for unbiased spatial transcriptomics, identifying spatial features linked to immunotherapy responses.
The findingWhy it mattersWhat they didThe result
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