Advanced Electron Microscopy Techniques and Applications
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Latest in Advanced Electron Microscopy Techniques and Applications
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Cryo-EM structures reveal a stepwise stabilization pathway and dual-site inhibition mechanism of the CCHFV polymerase, offering new insights into viral replication control.
- Open access
FoldaVirus predicts complete icosahedral viral capsids up to T=9 symmetry by integrating AlphaFold structures with known viral architectures.
- Open access
MemBrain v2 achieves highly accurate, generalizable membrane segmentation, particle localization, and quantitative analysis in cryo-electron tomography with minimal manual effort.
- Open access
- 178 cites
eEF2 is the dominant hibernation factor, binding to over 95% of 80S ribosomes and 60S subunits in mammalian cells, revealing a key role in cellular stress responses.
- Open access
E. coli RNA polymerase can efficiently transcribe an eight-letter genetic alphabet, including two orthogonal unnatural base pairs, with high fidelity and structural compatibility.
- Open access
A 3° tilt increment optimizes cryo-electron tomography data quality, balancing resolution, alignment, and efficiency in Dictyostelium discoideum studies.
- Open access
Self-supervised, physics-informed generative model produces highly realistic training data, boosting nanoscale localization accuracy in challenging microscopy conditions.
- Open access
- 1 cites
BA.3.2.1 spike enhances immune evasion by adopting a stable, closed conformation that limits receptor engagement and masks antibody sites, despite high ACE2 affinity.
- Open access
Computational screening identified a novel allosteric pocket on APOBEC3B with 13 candidate inhibitors, advancing potential tumor therapy options.
- Open access
- 1 cites
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