Liver physiology and pathology
Moving in Journal of hepatology, bioRxiv, Gastroenterology, The lancet. Gastroenterology & hepatology, Nature Communications, Gut, Nature reviews. Gastroenterology & hepatology, Blood.
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Latest in Liver physiology and pathology
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Blood-based biomarkers show promise for early detection and management of liver cancer but require further validation in clinical settings.
Actin cytoskeletal dynamics are essential for hepatic myofibroblast functions driving liver fibrosis, with smooth muscle α-actin upregulation marking activation.
Advances in surgical planning and molecular understanding have expanded the resectability of liver cancers, with a focus on hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
- 1 cites
Hepatocytes support pancreatic cancer liver metastasis by producing serine through a CXCL5-CXCR2-driven pathway, promoting tumor growth in the liver.
- Open access
Canonical Notch2 signaling is essential for the development, maintenance, and function of iron-recycling macrophages, with its disruption causing iron overload in mice.
- Open access
Multi-organelle signatures identified distinct cell states and metabolic adaptations in liver and pancreas tissues, revealing complex intra-zonal heterogeneity and stress responses.
Reverse bioengineering of liver-on-a-chip systems reveals developmental principles that outperform current models, with 80% of key developmental features captured.
- Open access
Vascular macrophage dysfunction causes bacterial translocation in cirrhosis, with 20-week murine models showing impaired gut-vascular interactions and increased systemic bacterial spread.
- Open access
- 10 cites
Pharmacological plasminogen reduction significantly enhances liver regeneration and decreases posthepatectomy liver failure in mice and humans, with tranexamic acid showing clinical promise.
- Open access
Blood flow-induced haemodynamic stress regulates liver sinusoidal endothelial cell Wnt signalling, controlling metabolic zonation in the liver.
- Open access
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