Hepatology

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CiRPM after hospitalization for acutely decompensated cirrhosis is linked to fewer 90-day liver-related readmissions versus C-control (39% vs 58%, HR 0.57, p=0.01).

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HBsAg-positive individuals should be screened at least once for HDV using HDV antibody testing, with RNA confirmation for antibody-positive cases.

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ATTEST (AI Transparency Tiered by Evidentiary Stakes) classifies AI assistance in scientific workflows into eight function categories scored across four evidentiary risk tiers.

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One year of elafibranor normalized alkaline phosphatase in phase III ELSPIRE trial patients with primary biliary cholangitis who had incomplete response to ursodeoxycholic acid, targeting ALP ≤ULN (≤120 U/L).

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MRI proton density fat fraction (MRI-PDFF) thresholds of 6.4%, 17.4%, and 22.1% stratify steatosis grades, and a ≥30% relative reduction links to histologic response in MASLD.

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B-BEST targeted sc/snRNA-seq resolves HBV replication-state heterogeneity in HBV-positive hepatocytes, linking specific host metabolic/mitochondrial programs to active viral transcription in HBeAg-positive patients.

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Transarterial radioembolization monotherapy is the only hepatocellular carcinoma (HCC) macrovascular invasion option with consistently low heterogeneity, yielding pooled 1-year overall survival of 34% (95% CI 20%–48%).

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In a multicenter trial of 89 patients with severe alcohol-associated hepatitis (MELD≥20), IL-1Ra treatment drove a day-7 IL-1Ra rise and broader cytokine shifts, while steroid therapy showed IL-1β elevation by day 28.

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Low Glul expression in CTNNB1-mutated hepatocellular carcinoma is linked to poor patient survival, highlighting glutamine synthetase as a key metabolic marker in this HCC subtype.

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In a national cohort of Veterans with cirrhosis undergoing 56,941 outpatient paracenteses, i.v. albumin use (17%) was linked to lower AKI-related hospitalization odds (OR 0.66).

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Aripiprazole prevents progression of MASH-induced hepatocellular carcinoma in rats, linked to antifibrogenic and anti-inflammatory modulation of liver fibroblasts and macrophages.

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Liver tissue RNA sequencing in 147 patients with genetic liver disease supported diagnoses in 56 cases from DNA-only results and added diagnoses in 17 previously undiagnosed patients (18.68%).

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OCE-205, a selective V1a mixed agonist-antagonist without V2 activity, was well tolerated in HRS-AKI, with bradycardia 21.6% and no ischemia or respiratory failure.

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Oral YAQ007 lowered ammonia by day 5 in cirrhosis patients with prior overt hepatic encephalopathy, with significant reductions at 4 g twice daily and 4 g three times daily.

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In Chinese adults with chronic hepatitis B, pradefovir mesylate achieved non-inferior HBV DNA suppression at week 48 versus tenofovir disoproxil fumarate, with HBeAg-positive and HBeAg-negative results within the -12% margin.