Intravenous albumin after outpatient paracentesis reduces the risk of AKI hospitalization: A national cohort study.

In a national cohort of Veterans with cirrhosis undergoing 56,941 outpatient paracenteses, i.v. albumin use (17%) was linked to lower AKI-related hospitalization odds (OR 0.66).

• Why it matters: Guidelines support i.v. albumin after large-volume paracentesis, but real-world outpatient evidence on AKI hospitalization outcomes has been limited.
• What they did: In 9467 Veterans, albumin administration and paracentesis volumes were analyzed with mixed-effects logistic regression for AKI hospitalization within 7 days, including dosing in 48,401 procedures.
• The result: Albumin showed lower AKI hospitalization odds overall (OR 0.66, p <0.001), with a stronger association at lower estimated glomerular filtration rates (interaction p=0.03); higher-dose albumin (≥6–8 g/L removed) had OR 0.36 (p=0.001).

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