The abstract is read at the publisher; the summary is JClub's.
MRI proton density fat fraction (MRI-PDFF) thresholds of 6.4%, 17.4%, and 22.1% stratify steatosis grades, and a ≥30% relative reduction links to histologic response in MASLD.
- Why it matters: Liver biopsy is invasive, prone to sampling error, and hard to scale, creating a need for noninvasive, quantitative biomarkers to support diagnosis, prognosis, and treatment response assessment in MASLD.
- What they did: The review summarizes evidence that MRI-PDFF quantifies whole-liver fat, while MRE-LS estimates fibrosis using 3.1–4.4 kPa for F2–F3 and ≥5 kPa for cirrhosis, and composite imaging–blood scores support advanced fibrosis diagnosis and response.
- The result: These MRI biomarkers enable noninvasive risk stratification and treatment-response monitoring, support regulatory and clinical-trial use, and may improve access via cost-effective MRE and AI automation for routine MRI analysis.
The findingWhy it mattersWhat they didThe result
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