Nature Biomedical Engineering

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An oral magnetoelectric particulate system that targets TRPV1 via capsaicin enables non-invasive vagus nerve stimulation through the gut, linked to enhanced norepinephrine and dopamine synthesis in Parkinson’s disease.

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RetiME, a deep learning biomarker from low-cost retinal photographs, robustly predicts all-cause and cause-specific mortality and reconstructs personalized lifespan trajectories linked to observed outcomes.

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A thermoresponsive positively charged PNIPAM/Ga3+ (PGa III) hydrogel sealant forms single-step Janus-type tissue adhesion and repairs gastrointestinal fistulas in rat and pig models.

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A closed-loop controller using real-time ultrasound flow measurement regulates spinal cord blood flow after spinal cord injury by adjusting norepinephrine infusion to target a predefined flow level.

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Biomimetic polyzwitterionic coacervates (pZCOs) form a stable ultralow-friction lubrication layer on cartilage and, in rat and mini-pig osteoarthritis, reduce cartilage degradation and inflammation.

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GradientScreen, a microfluidic ratiometric combination drug screening assay for high-risk paediatric acute lymphoblastic leukaemia, links drug response metrics to clinical outcomes, including MRD.

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Erythrocyte-derived microparticles generated by controlled ultraviolet irradiation enhance tumour antigen-specific cytotoxic T cell immunity in multiple mouse tumour models, skewing responses toward T helper type 1.

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AS2863619-loaded collagen hydrogels, especially with laponite nanoparticles, promote dose-dependent regulatory T cell activation and enhance bone regeneration in a calvarial bone-defect model.

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SpatialZoomer extracts multi-scale spatial molecular features from spatial transcriptomics, automatically identifying critical scales and detecting disease-progression signals in Alzheimer’s at specific resolutions.

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SPACER, an interpretable multi-instance learning model, improves recovery of gene-level cell recruitment signals by 4–21-fold across 37 spatially resolved transcriptomics datasets spanning human tumors and mouse heart.

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Continual learning adapted an adult deep learning model for neonatal endotracheal tube assessment, cutting anatomical landmark localization error to 0.67 cm versus 1.29 cm (fine-tuning) and 4.30 cm (adult-only) across 30 NICUs.

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A soft neural interface bioelectronic system (SNIBS) enables real-time intraoperative monitoring of craniocerebral injury, with contact pressure above 80 kPa linked to irreversible damage.

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MOF-Vac, a nanoscale metal-organic framework vaccine, induced tumour regression in murine models across melanoma, colorectal cancer, triple-negative breast cancer, lung cancer, and oropharyngeal cancer.

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Flexible, tissue-like electrode arrays enable stable, months-long single-neuron tracking in mouse visual cortex and hippocampus, supporting high-performance decoding despite representational drift.

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A glycosylated 18F-fluorodeoxyglucose-derived PET tracer selectively incorporates into Staphylococcus via the glucose-specific phosphotransferase transporter and detects live gram-positive infection with >6-fold higher signal than non-infected tissue in mice.

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Thoracic vertebral segment-specific spinal cord organoids (enTsOrg) restore hind-limb motor function in a spinal cord injury mouse model and enhance in vivo neuroelectric conduction.

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A microfluidic microphysiological model of the human placental barrier shows cadmium exposure in maternal flow links to impaired tissue function and adverse responses.

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Confined culture system (CCS) organoids generate large-scale human small intestinal, colonic, and gastric tissues with a de novo enteric nervous system, reaching 8 cm width after 10 weeks.

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Microphysiological organoid and organ-on-a-chip systems are increasingly enabling human-relevant modeling of gastrointestinal disease across inflammatory, infectious, and neoplastic conditions.