Realignment of representational drift in mouse visual cortex via flexible electrode arrays.

Flexible, tissue-like electrode arrays enable stable, months-long single-neuron tracking in mouse visual cortex and hippocampus, supporting high-performance decoding despite representational drift.

• Why it matters: Brain-computer interfaces and neural decoding are undermined by recording instability from immune responses and probe drifting, while representational drift changes neural codes over time.
• What they did: The study used flexible electrode arrays to record single-unit action potentials during repeated visual stimulation, then quantified representational drift and modeled population latent dynamics with geometric transformations across sessions.
• The result: A decoder built on aligned latent dynamics maintained high performance across long time spans and showed potential to generalize across different animals, despite ongoing neural representational shifts.

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