Translocation of the environmental bacterium Aquitalea magnusonii promotes systemic inflammation and liver fibrosis in chronic liver disease.

Aquitalea magnusonii translocation across the intestinal barrier is linked to systemic inflammation and liver fibrosis in chronic liver disease models, including ACLF-associated metabolite production.

• Why it matters: Impaired gut barrier integrity may allow non-commensal environmental bacteria to reach the liver and worsen chronic liver disease, but the specific pathogenic contribution of such microbes is unclear.
• What they did: The study combined patient blood analyses with multi-omics and tested A. magnusonii using human intestinal epithelial models, PBMC, hepatic stellate cells, monocytes, and alcoholic (ALD) and MASLD models, including gavage and cell-free supernatant assays.
• The result: A. magnusonii was detected in multiple organs in ALD and MASLD models, produced 12 ACLF-associated metabolites, and its supernatant activated TLR2- and TLR4-dependent inflammatory signaling, increasing inflammation and fibrosis in vitro and in vivo.

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