Salmonella infection and biofilms induce anti-C1q autoantibodies, exacerbating renal damage in lupus-prone mice, revealing a new autoimmune mechanism.
PLOS Pathogens
Public Library of Science · Microbiology & Mycology · ISSN 1553-7366, 1553-7374
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Hospitalized dengue patients produce fewer high-affinity, broadly reactive IgG-secreting cells compared to subclinical cases, with a threefold reduction in affinity for DENV1 E-dimers.
MARCHF5 and MCL1 cooperate to inhibit apoptosis in KSHV-transformed primary effusion lymphoma cells, with MARCHF5 promoting degradation of the pro-apoptotic protein NOXA.
Vpr hijacks the CRL4(VprBP) E3 ligase by utilizing flexible ARM-like domains to recruit diverse substrates, enabling targeted degradation of host restriction factors.
Genotyping ITS and cox1 markers misrepresents schistosome hybridization and zoonotic infection, with genome sequencing revealing no recent hybrids among human parasites.
Keratinocytes from asymptomatic HSV-2-infected individuals show significantly heightened IFNγ responses, especially at low doses, compared to symptomatic donors, influencing disease outcomes.
Elevated Plasmodium falciparum sexual conversion rates are observed in HbAC and HbAS red blood cells, increasing malaria transmission potential in infected individuals.
Sphingomyelin phosphodiesterase (Sph) from S. aureus promotes ferroptosis by disrupting mitochondrial function and activating the cGAS-STING pathway, contributing to mastitis pathology.
Methylglyoxal-dependent carbonyl stress pathway is active in Lyme disease spirochetes and influences their infection dynamics, but is absent in relapsing fever Borrelia.
Fish-specific E3 ubiquitin ligase NHRE3 degrades ISG15, suppressing antiviral immunity and facilitating GCRV infection in grass carp and rare minnow.
Immunopeptidomics identified 57 F. tularensis LVS peptides, including five dominant CD4+ T cell epitopes, that elicit immune responses in mice, aiding vaccine development.
Divergent mitochondrial complexes are an ancestral and conserved feature across Myzozoa, as shown by profiling Perkinsus marinus, revealing shared components with apicomplexans.
PfATG18 is essential for V-ATPase stability and vacuolar membrane dynamics, with its loss causing parasite death and vacuole fragmentation in Plasmodium falciparum.
Circoviruses hijack host PCNA to recruit POLD1, driving viral DNA replication, which can be inhibited by the drug R428, offering a potential treatment strategy.
High-density peptide array identified 283 immunogenic Plasmodium vivax proteins, revealing key targets involved in blood-stage infection and potential vaccine candidates.
Rickettsia parkeri transmits to host skin within 1 hour of tick attachment, with bacterial loads increasing rapidly over 144 hours.
Low water temperatures increase palmitoylation of SVCV glycoprotein, boosting viral replication by 50% in zebrafish cells.
A serine protease inhibitor from Trichinella spiralis reduces obesity and adipose inflammation by reprogramming macrophages via TIM-3 signaling in mice.
Loss of the potE-speF operon enhances Haemophilus influenzae survival in middle ear infections, with strains thriving in alkaline conditions and increasing disease burden by 63-fold.
m5C modification of HIV-1 RNA by NSUN2 enables the virus to evade RIG-I detection and enhances replication, with a 50% reduction in immune evasion when NSUN2 is depleted.
Targeted lysosomal activation by OM-89 boosts intracellular clearance of UPEC in bladder epithelium, reducing bacterial regrowth after antibiotics.
Divergent NSs proteins in Bhanja virus enhance interferon antagonism and viral replication across lineages, with up to 2-fold increased suppression of interferon-beta induction.
GM000287 is a conserved envelope protein essential for serum resistance and virulence in Klebsiella pneumoniae, impacting infection outcomes across diverse strains.
DVGs from specific genomic hotspots in SARS-CoV-2 differentially activate interferon responses, with hotspot B DVGs inducing significantly stronger immune stimulation.
Pyridoxal 5'-phosphate biosynthesis is essential for Plasmodium falciparum gametocyte transmission to mosquitoes, as revealed by translatome analysis of dormant stage V gametocytes.
U14 protein and PDLIM2 regulate NF-κB signaling termination, enabling productive HHV-6A infection, with U14 promoting viral replication through host interactions.
Nanopore sequencing reveals complex transcriptional architecture, including novel genes and modification patterns, in the large DNA virus ASFV, impacting understanding of its pathogenicity.
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