The abstract is read at the publisher; the summary is JClub's.
Loss of the KSHV nuclear egress complex (UL31/UL34) in iSLK-BAC16 cells causes capsid accumulation at the nuclear periphery and abolishes infectious virion production.
- Why it matters: The NEC’s function during lytic KSHV replication was unclear, despite evidence that NEC overexpression can remodel nuclear membranes in uninfected cells.
- What they did: Nuclear egress was assessed during KSHV reactivation in iSLK-BAC16 and TREx-BCBL1-RTA using transmission electron microscopy, comparing NEC loss effects and egress kinetics.
- The result: Capsid egress and virion assembly occurred in both lines, but nuclear membrane remodeling was extensive in iSLK-BAC16 and largely reduced in TREx-BCBL1-RTA, with egress proceeding more rapidly in TREx-BCBL1-RTA.
The findingWhy it mattersWhat they didThe result
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