Journal of hepatologyJClub
MRI-based prediction of very early recurrence within 1 year after resection of HCC: An international cohort study.
Journal of hepatology · · Multicenter Study · Open access
Wei, Heo + more
Abstract ↗AI summary
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MRI-based MERP-pre and MERP-post models predict 1-year very early recurrence after curative resection of single BCLC 0/A hepatocellular carcinoma, with C-index 0.685–0.790.
- Why it matters: Very early recurrence within 1 year signals aggressive HCC biology, but non-invasive prediction tools are scarce for patients undergoing curative-intent resection.
- What they did: In an international multicenter cohort of 1,811 patients plus 40 TCGA-LIHC cases, MERP-pre used preoperative MRI variables and MERP-post added postoperative microvascular invasion, then was externally validated in Eastern (n=775) and Western (n=178) cohorts and tested in CT (n=230).
- The result: Across test cohorts, MERP models outperformed major staging systems and IMbrave050 (C-index 0.685–0.790 vs. 0.524–0.682; p<0.001 to 0.046), stratified distinct 1-year RFS groups (all p<0.001), and MERP-pre low-risk tumors showed non-proliferative, lipid-catabolism, and immunoactive microenvironment features.
The findingWhy it mattersWhat they didThe result
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