The hepato-exposome axis: How endocrine disruptors hijack liver receptors to drive MASLD.

Endocrine-disrupting chemicals are linked to MASLD by imprinting overlapping hepatic molecular signatures on lipid, glucose, mitochondrial, antioxidant, and inflammatory pathways through nuclear receptor interfaces.

• Why it matters: MASLD is rising faster than obesity, diet, or genetics alone can explain, and mechanistic links to environmental endocrine disruptors remain to be mapped.
• What they did: This review synthesizes in vivo and in vitro evidence to build the “hepato-exposome axis,” mapping EDC families (e.g., bisphenols, phthalates, PFAS) to metabolic and xenobiotic-sensing nuclear receptors (AhR, PXR, CAR, PPARs, FXR, LXRs, RXR).
• The result: The integrated evidence suggests EDC exposure can foster a pro-steatotic and pro-inflammatory hepatic milieu, informing research priorities like mixture toxicology, multi-omics exposome profiling, and biomarker discovery.

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