Research area · week to 3 Oct 2026

Liver Diseases and Immunity

Moving in Journal of hepatology, Gut, Gastroenterology, Nature reviews. Gastroenterology & hepatology, Cell Metabolism, Cell Reports, Nature Medicine, The lancet. Gastroenterology & hepatology.

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Relieving IBD with duvakitug.
Nature reviews. Gastroenterology & hepatology · 1 Oct 2026 · Journal Article
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B cell-guided inflammatory cascade perpetuates ICI-mediated colitis.
Cell Reports · 22 Sept 2026 · Journal Article
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Trastuzumab plus nivolumab with gemcitabine and cisplatin as first-line therapy for HER2-positive unresectable biliary tract cancer: a phase 1b/2 trial.
Nature Medicine · 22 Sept 2026 · Journal Article
A HER2-targeted quadruplet regimen achieved a 55% objective response rate in first-line treatment of HER2-positive unresectable biliary tract cancer, showing promising efficacy.
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High rates of transition to immune active disease in a cohort of strictly defined immune tolerant patients with chronic hepatitis B: results from the RADICAL consortium.
Gut · 18 Sept 2026 · Journal Article
Over 50% of strictly defined immune tolerant chronic hepatitis B patients transition to immune active disease within five years, especially those with high-normal ALT levels.
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Glutamine metabolism as a rheostat of CD4(+) T cell pathogenic function in metabolic dysfunction-associated steatotic liver disease.
Cell Metabolism · 18 Sept 2026 · Journal Article
Hepatic glutamine metabolism critically regulates pathogenic CD4(+) T cell inflammation, with Gln depletion linked to increased liver damage in MASLD.
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Nucleos(t)ide analogue therapy for EASL immune-tolerant phase hepatitis B.
Gut · 7 Sept 2026 · Letter
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Impact of Family History on Colorectal Cancer Risk in Inflammatory Bowel Disease and in Matched General Population Comparators.
Gastroenterology · 3 Sept 2026 · Journal Article
Family history of colorectal cancer increases CRC incidence similarly in IBD patients and the general population, especially with multiple affected relatives, but the relative impact is weaker in IBD.
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A call for action: The need to quantify the "-itis" in primary sclerosing cholangitis.
Journal of hepatology · 1 Sept 2026 · Letter
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Delphi consensus in primary biliary cholangitis: Collective introspection to set a path forward.
Journal of hepatology · 1 Sept 2026 · Editorial
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Histopathology matters for imaging and clinical correlations in primary sclerosing cholangitis.
Journal of hepatology · 1 Sept 2026 · Letter
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Single-nucleus profiling reveals hepatocyte identity and immune features associated with corticosteroid response in severe alcohol-related hepatitis.
Journal of hepatology · 1 Sept 2026 · Multicenter Study
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Primary sclerosing cholangitis: Time to rethink imaging criteria for early disease detection.
Journal of hepatology · 1 Sept 2026 · Letter
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Gastrointestinal Disorders in Scleroderma.
Gastroenterology · 1 Sept 2026 · Review
Gastrointestinal involvement affects up to 90% of systemic sclerosis patients, causing diverse symptoms from esophageal dysphagia to colonic dilation.
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EASL-AASLD Delphi consensus statement on surrogate endpoints and real-world evidence in primary biliary cholangitis.
Journal of hepatology · 1 Sept 2026 · Consensus Statement
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A decade of progress in cholestatic liver diseases: navigating a new era.
The lancet. Gastroenterology & hepatology · 1 Sept 2026 · Journal Article
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Clonal Lymphocyte Expansions and JAK-STAT Pathway Mutations Define a Pathogenic Continuum Driving Resistance to Gluten-Free Diet in Celiac Disease.
Gastroenterology · 1 Sept 2026 · Journal Article
Clonal lymphocyte expansions with JAK-STAT mutations drive gluten-free diet resistance in type 2 refractory celiac disease, revealing a pathogenic continuum.
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Elafibranor in primary biliary cholangitis: two-year placebo-controlled outcomes and long-term open-label data from the ELATIVE® phase III trial.
Journal of hepatology · 27 Aug 2026 · Journal Article
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Chronic liver disease is associated with earlier-stage cholangiocarcinoma diagnosis and improved prognosis: Findings from the GLOBAL-BTC registry.
Journal of hepatology · 24 Aug 2026 · Journal Article
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Sexual dimorphism in the liver.
Nature reviews. Gastroenterology & hepatology · 19 Aug 2026 · Review
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Cryptogenic steatotic liver disease reveals hidden liver risk in metabolically silent lean individuals.
Gut · 18 Aug 2026 · Journal Article
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Internal Inconsistencies in the Training-Cohort Performance Table for the ELM Score.
Journal of hepatology · 17 Aug 2026 · Letter
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Hepatitis B Surface Antigen Loss and Hepatocellular Carcinoma Surveillance: One Size Does Not Fit All.
Gastroenterology · 17 Aug 2026 · Editorial
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Neutralising autoantibodies against IL-10 and HLA-DRB1*01:03 in paediatric patients with inflammatory bowel disease.
Gut · 11 Aug 2026 · Journal Article
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PCK1 deficiency promotes MASH-HCC progression by 12-HETE-induced CD8(+) T cell dysfunction.
Gut · 6 Aug 2026 · Journal Article
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Dysbiotic microbiota trigger colitis-associated colorectal cancer and imprint a distinctive bile acid profile in a PSC-IBD model.
Gut · 6 Aug 2026 · Journal Article
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Autophagy of Kupffer cells modulates CD8(+) T cell activation in primary biliary cholangitis.
Gut · 6 Aug 2026 · Journal Article
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Anti-TNF therapy in autoimmune hepatitis: We should move faster.
Journal of hepatology · 5 Aug 2026 · Letter
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