AI-driven multimodal models improve prediction of recurrence and survival in liver cancer, surpassing single-modality approaches in accuracy.
- Open access
Hepatocellular Carcinoma Treatment and Prognosis
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Latest in Hepatocellular Carcinoma Treatment and Prognosis
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Blood-based biomarkers show promise for early detection and management of liver cancer but require further validation in clinical settings.
Liver cancer surveillance faces limited support due to lack of randomized trial evidence, with false positives and low sensitivity impacting effectiveness.
- Open access
- 1 cites
Primary liver cancer cases and deaths increased by over 55% globally from 2000 to 2023, reversing previous declines and highlighting urgent public health needs.
- Open access
Actin cytoskeletal dynamics are essential for hepatic myofibroblast functions driving liver fibrosis, with smooth muscle α-actin upregulation marking activation.
AI-driven multimodal models improve prediction of recurrence and survival in liver cancer, surpassing single-modality approaches in accuracy.
- Open access
Immune checkpoint inhibitor combinations have become the standard first-line systemic therapy for HCC, significantly improving survival and response rates over previous treatments.
- Open access
Integrating systemic therapy earlier in liver cancer shows promising but uncertain benefits, with advances in hepatocellular carcinoma and biliary tract cancers.
- Open access
Recent advances in liver cancer imaging have enhanced detection, characterization, and prognostication, with key developments in ultrasound, CT, MRI, PET, and computational analysis.
- Open access
- 1 cites
Advances in surgical planning and molecular understanding have expanded the resectability of liver cancers, with a focus on hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
- 1 cites
YAP1 induces hepatocellular carcinoma through DNA demethylation, not canonical driver gene mutations, with widespread demethylation activating oncogenes in mouse models.
- Open access
Pharmacological plasminogen reduction significantly enhances liver regeneration and decreases posthepatectomy liver failure in mice and humans, with tranexamic acid showing clinical promise.
- Open access
Abbreviated MRI protocols and blood-based biomarkers show promise for improving hepatocellular carcinoma surveillance accuracy and patient adherence.
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