AI-driven framework AGENT rapidly identified thermostable mRNA-LNP vaccine formulations, achieving 100% bioactivity after 2 months at 37°C in just six iterations.
Nature Biotechnology
Nature Portfolio · Genomics & Bioinformatics · ISSN 1087-0156, 1546-1696
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Machine-learning-designed minimal ligand-binding domains enable efficient allosteric switches without global conformational change, facilitating diverse biosensors and synthetic systems.
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Deep learning genetic perturbation models outperform uninformative baselines when evaluated with calibrated metrics across multiple datasets.
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Lipid nanoparticle LC-1 achieves up to 79% genome editing efficiency with large 5.7-kb mRNA cargo, outperforming existing formulations across multiple tissues.
AI-driven framework AGENT rapidly identified thermostable mRNA-LNP vaccine formulations, achieving 100% bioactivity after 2 months at 37°C in just six iterations.
scSTAMP-seq enables high-resolution spatial transcriptomics and epigenomics in single cells with over 10,000 cells analyzed in human embryoids.
Engineered MspA-FPBA nanopore achieves 98.7% accuracy in identifying proteins, RNAs, glycans, and peptides simultaneously, covering 34 analyte types.
Six proteomic aging clocks consistently predicted lower biological age in a 12-week clinical trial of rentosertib for idiopathic pulmonary fibrosis.
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Engineered attB(V111) site achieves up to 51.9% integration efficiency in human cells and 35.6% in rice, greatly enhancing site-specific recombination in plants and human cells.
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Guide RNAs co-purify during RNA extraction and cause a significant overestimation of RNA knockdown efficiency in RT-qPCR measurements across all tested CRISPR systems.
Epigenetic programming in primary human T cells using an all-RNA CRISPR platform enables durable gene regulation without DNA breaks, achieving stable gene silencing or activation.
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Growth-coupled biosynthesis in Pseudomonas putida achieves gram-scale xanthommatin production by linking pigment synthesis to C1 metabolism, reaching significant bioproduction levels.
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DIAL enables precise, heritable tuning of transgene expression through programmable promoter editing, achieving stable, heritable setpoints in primary and stem cells.
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De novo mitotic errors, including multipolar spindles and lagging chromosomes, occur frequently in late-stage preimplantation human embryos, with most lagging chromosomes passively inherited.
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AdaptiveFlow enables ultralarge virtual screenings of 69 billion molecules, identifying nanomolar inhibitors for disease-relevant targets at unprecedented scale.
Folding-mediated secretion using ProAla mutations yields highly pure bispecific antibodies with 100% correct pairing in IgG-like formats.
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Biophysical analyses reveal that lipid nanoparticle (LNP) size, shape, and RNA loading vary with formulation technique and lipid composition, impacting transfection efficiency.
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Conserved, cell type-specific RNA sequestration in P-bodies directs stem cell fate transitions across vertebrates, enabling control over cell identity.
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