Scaling DNA synthesis with a microchip-based massively parallel synthesis system.

Nature Biotechnology · 1 Nov 2026 · Journal Article · Open access

Zhang, Jiang + more

The abstract is read at the publisher; the summary is JClub's.

A microchip-based massively parallel DNA synthesis system boosts synthetic oligonucleotide concentration by four to six orders of magnitude using an identification-sorting-synthesis-recycling iteration scheme.

Why it matters: Existing high-throughput DNA synthesis relies on complex chip and microfluidic setups that yield low concentration and can be poorly compatible with long DNA assembly.
What they did: The authors implement an identification-sorting-synthesis-recycling iteration mechanism on microchips to run DNA synthesis in massive parallel and then recycle components.
The result: The method raises DNA product concentration by four to six orders of magnitude and streamlines downstream steps for large-scale gene synthesis.

AI summary of the abstract · may contain errors · not medical advice · read the paper.

Open access
14 cites

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Scaling DNA synthesis with a microchip-based massively parallel synthesis system.

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