Lactate dehydrogenase A-dependent redox control of selective mRNA translation directs monocyte fate commitment.

LDHA-dependent redox control of mRNA translation directs monocyte fate commitment to NOS2+ macrophages in vivo.

• Why it matters: Understanding how metabolism influences monocyte differentiation is crucial for modulating immune responses, especially during inflammation and infection.
• What they did: A CRISPR-based metabolic screen and monocyte-specific experiments in bacterial lung infection identified LDHA as a key regulator, revealing that NAD+ regeneration enables selective HIF1α translation via its 5' UTR, with GM-CSF acting as an upstream priming signal.
• The result: Findings suggest that the cellular redox state influences monocyte fate by regulating mRNA translation through RNA structural remodeling, providing insights into metabolic control of immune cell differentiation.