Neural iterative selection-expansion (NISE) enables zero-shot design of small-molecule binding proteins with nanomolar affinities, achieving success rates up to 100%.
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Protein Structure and Dynamics
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Genetic variation influences in vivo protein-protein interactions in yeast, with 12,000 SNPs revealing 61 reporter PPIs and numerous piQTLs.
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PIONEER2 outperforms AlphaFold3 in predicting protein-protein interfaces, especially for uncertain and unstructured complexes, enabling comprehensive human interactome analysis.
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FORGE accurately recovers 64.6% of native nucleotides from RNA tertiary structure geometry, surpassing simpler controls and revealing residue-level information.
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