Shaping the future of early-onset colorectal cancer prevention.

Early-onset colorectal cancer (EOCRC) cases under age 50 are rising globally, with lifestyle and early-life factors contributing to the increasing burden.

• Why it matters: Understanding the specific risk factors and their timing is crucial to developing effective prevention strategies for younger populations, who face unique challenges.
• What they did: A transdisciplinary framework integrating population, mechanistic, behavioral, and implementation sciences was proposed, supported by global initiatives like Cancer Grand Challenges PROSPECT.
• The result: This approach aims to accelerate causal risk factor discovery and translate insights into prevention strategies, emphasizing collaboration and public engagement to reduce EOCRC incidence.