The abstract is read at the publisher; the summary is JClub's.
Type 2 diabetes mellitus is linked to higher odds of incident colorectal cancer, with a pooled OR of 1.28 (95% CI 1.13–1.46) from observational studies.
- Why it matters: Earlier meta-analyses were often outdated and mixed different epidemiologic effect measures, leaving uncertainty about the updated magnitude of the T2DM–CRC association.
- What they did: An updated systematic review and meta-analysis searched PubMed, Embase, Web of Science, CENTRAL, and Scopus for observational studies from January 2012 to January 2026, pooling effects with random-effects models.
- The result: Across studies, T2DM also showed higher incident CRC hazard (HR 1.27; 95% CI 1.23–1.31) and higher CRC incidence in the single SIR report (SIR 1.40; 95% CI 1.39–1.45), with sex-specific and sensitivity analyses supporting robustness.
The findingWhy it mattersWhat they didThe result
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