SPROUT Guidelines for Molecular Profiling for Children with Solid Tumors: A Consensus Recommendation from the American Association for Cancer Research.

SPROUT consensus guidelines standardize DNA/RNA next-generation sequencing and methylation profiling timing for children with pediatric solid tumors, based on 41 included studies.

• Why it matters: Molecular diagnostics are routine for many adults, but pediatric solid tumor testing is inconsistent, limiting diagnostic precision and biomarker-driven options.
• What they did: The SPROUT Working Group conducted a structured literature review (361 screened, 41 included) and combined evidence with multidisciplinary clinical experience to draft consensus recommendations.
• The result: The framework supports standardized molecular testing at diagnosis and at relapse or recurrence, aiming to reduce variability and expand biomarker-directed therapy and trial enrollment.

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