Neutrophils are known by their neighbors in breast cancer.

Two distinct neutrophil niches in triple-negative breast tumors are linked to different clinical outcomes, with tumor-proximal neutrophils tied to favorable prognosis.

• Why it matters: Neutrophils are present in tumors, but how their spatial organization relates to prognosis and treatment response is unclear in triple-negative breast cancer.
• What they did: Xu et al. integrated large-scale computational pathology with spatial omics and then validated key roles using functional experiments to map neutrophil neighborhoods.
• The result: Neutrophils near immune cells are associated with immunotherapy response, enabling spatially informed interpretation of neutrophil biology in triple-negative breast cancer.

AI summary of the abstract · may contain errors · not medical advice · read the paper.