Cancer DiscovJClub
A Pan-Cancer Single-Cell Analysis of Intratumoral Copy-Number Diversity and Evolution.
Cancer Discovery · · Journal Article
Ye, McDonald + more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
Single-cell profiling of 94 human tumors shows intratumoral aneuploid copy number diversity is linked to higher CNA burden and whole genome doubling, across 62,646 aneuploid cells.
- Why it matters: Patient-level CNA differences are well studied, but how copy number heterogeneity evolves within tumors is still unclear, limiting understanding of intratumoral evolution.
- What they did: The team profiled 62,646 aneuploid cells from 94 tumors spanning seven cancer types using single-cell copy number profiling, plus bulk exome sequencing and single-nucleus RNA-seq of 6 samples.
- The result: Tumor cells within each patient shared truncal CNAs, and many tumors accumulated CNAs in bursts, implying punctuated evolution is common across diverse cancer types.
The findingWhy it mattersWhat they didThe result
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