Spatial and regulatory organization of cell identity across the primate subcortex.

A spatially resolved transcriptomic and gene regulatory atlas across the common marmoset subcortex reveals spatially precise neuronal assemblies and enhancer-linked transcription factor gradients.

• Why it matters: Cell identity depends on both intrinsic programs and external spatial context, but how regulatory logic varies across primate subcortical regions is unclear.
• What they did: The study built a dense-sampling transcriptomic and chromatin accessibility atlas across all subcortical regions in the common marmoset, integrating across species to map regulatory syntax.
• The result: It shows that chromatin accessibility and transcriptional identity are spatially tuned, with hippocampal subfield gradients coordinated by graded transcription factors through graded enhancers, and that shared regulatory programs can occur across distant cell types.

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