Harmonized brain ontology and 3D atlases for human, macaque, and marmoset basal ganglia.

An iterative, cross-species harmonization effort produced HOMBA, a formal ontology and 3D-mappable basal ganglia framework spanning human, macaque, and marmoset brains.

• Why it matters: The work addresses the need for shared cellular taxonomies and structural parcellations that bridge neuroimaging with cellular and histological detail across primate species.
• What they did: It co-created structural and cellular ontologies for human, macaque, and marmoset basal ganglia and mapped/refined structural parcellations into neuroimaging-based common coordinate frameworks.
• The result: The resulting references standardize BICAN experimental sampling documentation and enable analyses of cellular and molecular variation by topographic position, supporting cross-species comparisons of cellular, molecular, and functional variation.

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