Mapping primate brain aging across cell types, regions, and sexes.

A single-nucleus atlas of the aging macaque brain maps context-dependent aging programs across cell types and regions, revealing sex-biased transcriptional aging and Alzheimer’s disease–linked molecular changes.

• Why it matters: Aging is the major risk factor for neurodegenerative disease, but its cell-type– and region-specific effects in the primate brain are not well defined.
• What they did: Yang et al. built a single-nucleus atlas of aging macaque brain and integrated it with related recent work by Zhang et al. to assess context dependence, sex effects, and disease-linked molecular signals.
• The result: The combined analyses identify context-dependent aging programs, sex-biased transcriptional aging, and molecular links to Alzheimer’s disease, clarifying how primate brain aging varies by cellular context and sex.

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