Morphoelectric diversity and specialization of primate striatal neuron types.

Multimodal Patch-seq in macaque striatum reveals underappreciated morphoelectric diversity among spiny projection neurons and interneurons, including non-canonical types and primate-specific features.

• Why it matters: Most cellular knowledge of basal ganglia circuits comes from rodents, leaving gaps in humans and translationally relevant primates where dysfunction contributes to neurological and psychiatric disorders.
• What they did: The study generated multimodal Patch-seq data linking transcriptomic identity to morphological and electrophysiological properties in macaque striatum, then mapped diversity across neuron classes and spatial gradients.
• The result: Morphoelectric properties vary along functional gradients for SPNs and show even greater diversity for interneurons, enabling a molecular-to-cellular framework for primate striatal functional organization.

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