Cross-species multiomic atlas of the primate basal ganglia.

A cross-species multiomic atlas of 1.8 million basal ganglia nuclei across humans, macaques, and marmosets identifies 61 conserved homologous cell types across 76 million years.

• Why it matters: A unified taxonomy of basal ganglia cell types is missing, limiting how researchers compare evolution and interpret neurological and psychiatric disease risk across species.
• What they did: The team integrated gene expression, open chromatin, and spatial profiling across eight basal ganglia structures, aligning species data to mouse and human whole-brain atlases.
• The result: Conserved cis-regulatory sequence grammars encode cell identity and enable cell-type-resolved mapping that localizes psychiatric and neurodegenerative risk to specific basal ganglia cell populations.

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