The abstract is read at the publisher; the summary is JClub's.
A cellular-resolution spatial transcriptomics atlas of human and nonhuman primate basal ganglia maps over one million cells per species, revealing stereotyped multi-axis gene expression gradients and internal globus pallidus core-shell organization.
- Why it matters: Basal ganglia nuclei have complex topography linked to goal-directed behavior and neurodegenerative movement disorders, but molecular organization across structures and species remains difficult to resolve in situ.
- What they did: The study generated spatial transcriptomics atlases for human, rhesus macaque, and common marmoset, integrating spatial data with a cross-species consensus snRNA-seq cell-type taxonomy and sampling across the rostral-caudal axis.
- The result: It uncovers highly stereotyped gene expression gradients across striatal compartments and core-shell organization in the internal globus pallidus, providing a foundational resource for studying basal ganglia organization in health and disease.
The findingWhy it mattersWhat they didThe result
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