Multimodal clocks of human aging.

Multimodal aging clocks accurately quantify human biological age and reveal coagulation factors as key drivers of multi-organ senescence.

• Why it matters: Understanding the heterogeneity of human aging and identifying reliable biomarkers are critical for developing targeted interventions and improving healthspan.
• What they did: The study developed the mCAS cohort with 2,019 Chinese individuals and integrated clinical, physiological, and molecular data to create three aging clocks, including plasma protein-based systems.
• The result: The clocks effectively measure biological age, with plasma proteins serving as proxies for systemic capacity, and identified coagulation factor accumulation as a novel driver of systemic aging processes.