Eternal life.

JAMA · 3 Nov 2026 · Journal Article

O'Sullivan

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Stochastic failure accumulation as a foundation for exponential mortality and selective disappearance
bioRxiv · 1 Nov 2026 · Preprint
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Greater interdependence among stochastic, failure-and-repair sub-systems within individuals is linked to faster demographic senescence, yielding population-level mortality curves derived via diffusion approximations.
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https://jclub.com.au/a/10.64898/2026.05.25.727614
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DNA polymerase kappa supports repair-associated DNA synthesis and genome maintenance in postmitotic neurons
bioRxiv · 1 Nov 2026 · Preprint
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Neuron-directed loss of POLK in primary mouse cortical neurons and human iPSC-derived forebrain neurons reduces EdU incorporation and triggers a senescence-like stress program, including nuclear-envelope defects and altered APP/lysosomal pathways.
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https://jclub.com.au/a/10.64898/2026.10.01.756094
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Alignment-Free k-mer Analysis Reveals Age-Associated k-mer Signals in Canine Buccal DNA and Cell-Free DNA
bioRxiv · 30 Oct 2026 · Preprint
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Alignment-free k-mer analysis identifies age-associated sequence composition signals in canine buccal DNA (1,187 samples) and cfDNA (100 samples), with stronger patterns in buccal DNA.
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https://jclub.com.au/a/10.64898/2026.10.24.761006
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Stochastic failure accumulation as a foundation for exponential mortality and selective disappearance

DNA polymerase kappa supports repair-associated DNA synthesis and genome maintenance in postmitotic neurons

Alignment-Free k-mer Analysis Reveals Age-Associated k-mer Signals in Canine Buccal DNA and Cell-Free DNA

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