Research area · week to 3 Oct 2026

SARS-CoV-2 and COVID-19 Research

Moving in eLife, JAMA, mBio.

Moved this week: 3

Rebuilt 3 October 2026 at 2:02 pm AEST

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FDA Approves Updated COVID-19 Vaccines for 2026-2027.
JAMA · 25 Sept 2026 · News
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Identification and characterization of a SARS-CoV-2 M(pro) G23 deletion ensitrelvir-resistant mutant.
mBio · 8 July 2026 · Journal Article
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https://jclub.com.au/a/42233671
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Viral commitment to infection depends on host metabolism.
eLife · 20 Aug 2026 · Journal Article
Viral attachment to Escherichia coli significantly decreases under energy-limited conditions, with weaker-binding phages being most affected, impacting infection success.
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https://jclub.com.au/a/42622628
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Latest in SARS-CoV-2 and COVID-19 Research

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The changing face of UK academic drug screening in the past decade.
Nature Reviews Drug Discovery · 1 Oct 2026 · Letter
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https://jclub.com.au/a/42477486
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vartracker: an end-to-end tool for pathogen longitudinal variant analysis and visualisation
bioRxiv · 30 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.06.723370
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Genetic variation in HLA, IGKV, and HHEX loci influences mRNA vaccine-induced humoral protection against COVID-19.
Cell Reports · 29 Sept 2026 · Journal Article
Genetic variation in HLA, IGKV, and HHEX loci significantly influences COVID-19 vaccine-induced neutralizing antibody responses and protection, with HLA linked to reduced breakthrough infections.
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https://jclub.com.au/a/42814572
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Integrated analysis of COVID-19 multi-omics data for eQTLs reveals genetic mechanisms underlying disease severity
bioRxiv · 29 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.12.18.629144
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Nsp3 Ubl1-orchestrated dephosphorylation of N protein promotes coronaviral subgenomic RNA synthesis
bioRxiv · 26 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.25.754410
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Rethinking seasonal COVID-19 vaccination in the endemic era: summer timing, eligibility, and frequency in the United States
medRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.23.26363810
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Direct and indirect effects of COVID-19 on infant bronchiolitis: a population-wide registry study from Northern Italy
medRxiv · 23 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.22.26363663
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Inhibiting the interaction between the mitochondrial receptor Tom70 and SARS CoV 2 Orf9b with small molecules
bioRxiv · 21 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.27.721040
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Mutational constraints on RSV F and its neutralization by antibodies.
Nature · 16 Sept 2026 · Journal Article
Mutations in RSV F protein influence antibody neutralization, with resistance mutations emerging sporadically but remaining rare in circulating strains.
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Convergent use of aminopeptidase N receptor by hedgehog merbecoviruses.
Nature Microbiology · 16 Sept 2026 · Journal Article
Hedgehog aminopeptidase N (APN) serves as a functional receptor for European and Asian hedgehog merbecoviruses, with a unique binding mode distinct from other coronaviruses.
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Deletion of the Envelope gene attenuates SARS-CoV-2 infection by altered Spike localization and increased cell-to-cell transmission
bioRxiv · 14 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.05.20.655126
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Divergent antibody-mediated population immunity to H5, H7 and H9 subtype potential pandemic influenza viruses
medRxiv · 11 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.08.25335309
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Functional Characterization of SARS-CoV-2 3CLpro Variants
bioRxiv · 10 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2025.12.23.696280
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Rapid turnaround multiplex sequencing of SARS-CoV-2: comparing tiling amplicon protocol performance
medRxiv · 8 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2021.12.28.21268461
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Sex differences in vaccine-induced neuraminidase cross-recognition impact H5N1 dissemination to the lower respiratory tract in mice
bioRxiv · 4 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.26.728011
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A viral ORFeome.
Nature Methods · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42697991
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Molecular-level observation of the self-assembly of a virus-like particle.
Nature · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42749916
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SARS-CoV-2 Delta variant-specific ORF3a mutations destabilize lysosomal homeostasis to trigger lysosomal damage-mediated cell death.
Communications Biology · 31 Aug 2026 · Journal Article
Delta variant-specific ORF3a mutations destabilize lysosomal homeostasis, causing lysosomal damage that triggers inflammatory cell death in SARS-CoV-2.
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https://jclub.com.au/a/42675129
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Mechanisms of sex differences in acute and long COVID sequelae in mice
bioRxiv · 27 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.13.682101
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Identification of a set of endogenous retroviruses linked to IL-1-mediated immunopathology in severe COVID-19.
bioRxiv · 26 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.07.08.737320
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Quantitative modeling of SARS-CoV-2 replication reveals phase-specific bottlenecks and antiviral targets
bioRxiv · 26 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.23.733955
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Combinatorial group testing for efficient scaling across biological applications.
Nature Communications · 25 Aug 2026 · Journal Article
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https://jclub.com.au/a/42660940
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Viral commitment to infection depends on host metabolism.
eLife · 20 Aug 2026 · Journal Article
Viral attachment to Escherichia coli significantly decreases under energy-limited conditions, with weaker-binding phages being most affected, impacting infection success.
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https://jclub.com.au/a/42622628
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Disentangling the drivers of heterogeneity in SARS-CoV-2 transmission from data on viral load and daily contact rates
medRxiv · 18 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.08.15.24311977
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Structural Definition of Neutralizing Epitopes within and around the HKU1 Receptor-binding Site Reveals Cell Context-Dependent Neutralization
bioRxiv · 17 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.29.685445
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Epistasis and the changing fitness landscapes of SARS-CoV-2
bioRxiv · 17 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.12.711354
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APP and APLP2 Kunitz Domains Are Potent Endogenous Inhibitors of TMPRSS2 and Respiratory Virus Infection
bioRxiv · 14 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.13.744607
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Dirty mice better recapitulate key features of mRNA vaccine immunogenicity observed in humans.
mBio · 12 Aug 2026 · Journal Article
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https://jclub.com.au/a/42405763
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Phagocytosis of SARS-CoV-2 Nucleocapsid- and RNA-Containing Immune Complexes Drives Inflammatory Cytokine Production and Endothelial Dysfunction
bioRxiv · 12 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.09.717495
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Antiviral Therapies for Adults With Mild to Moderate COVID-19 Infection.
JAMA · 11 Aug 2026 · Journal Article
IDSA recommends antiviral treatments for mild to moderate COVID-19 in adults, updating guidelines for 2025 to improve patient outcomes.
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