bioRxiv · 20 Sept 2026 · Preprint · Open access

Exploiting HSD17B11-dependent dialkynylcarbinols cytotoxicity for facile CRISPR/Cas9-based gene inactivation

Dumais, Bossaert + 12 more

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RNA-Triggered Chromatin Shredding Hits Cancer's Hardest Targets.
Cancer Discovery · 23 June 2026 · News
RNA-triggered chromatin shredding using Cas12a2 selectively eliminates tumor cells with mutations in critical cancer genes like TP53 and MYC in mouse models.
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Optimised genome editing for precise DNA insertion and substitution using prime editors in zebrafish.
eLife · 7 July 2026 · Journal Article
Prime editors achieve up to 27.3% precise DNA insertions in zebrafish, enabling accurate genome modifications without exogenous DNA.
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