The abstract is read at the publisher; the summary is JClub's.
DC-TAP-seq across 9,666 random distal element–gene pairs shows most distal elements that reduce expression have effect sizes under 10%, revealing prior underpowered detection limits.
- Why it matters: Distal regulatory effects are hard to measure because large CRISPR screens miss small element–gene interactions due to selection bias and limited statistical power.
- What they did: The study used Direct-Capture Targeted Perturb-seq with unbiased target selection and a statistical-power-aware pipeline to survey 9,666 random distal element–gene pairs.
- The result: Among 84 negative interactions, 45 (53.6%) were within 100 Kb of the target promoter, and the prevalence of small-effect elements implies future maps and models must account for <10% effects.
The findingWhy it mattersWhat they didThe result
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