Journal of the American College of Cardiology

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Left atrial appendage closure (LAAC) RCTs in atrial fibrillation are heterogeneous, so pooled estimates may not apply to a single patient group or decision.

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Right ventricular dysfunction is a key determinant of outcomes in valvular heart disease, with tricuspid regurgitation–associated dysfunction identifying patients at risk of worse post-intervention RV function.

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Three months of DOAC therapy after TAVR reduced hypoattenuated leaflet thickening (HALT) at 3 months versus lifelong single antiplatelet therapy, 12.1% vs 31.8%.

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In symptomatic paradoxical low-flow, low-gradient aortic stenosis, TAVR plus optimal medical therapy did not significantly reduce 2-year all-cause mortality versus optimal medical therapy alone (29.0% vs 37.1%).

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In the ENCIRCLE MAC Registry, transseptal TMVR with the SAPIEN M3 system achieved MR ≤1+ in 98.5% of implanted patients at 1 year for symptomatic MAC-related MVD.

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A coordinated community- and family-based intervention in rural China reduced systolic blood pressure distribution at 6 months, with an adjusted between-group SBP change of -10.7 mm Hg.

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In the China Rural Hypertension Control Project (CRHC), improving cardiovascular health via intensive blood pressure management is linked to lower cardiovascular risk, with the strongest effect in BP-plus-behavior/metabolic patterns (HR: 0.57).

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In 2019, county-level cardiovascular disease mortality in the United States was 237.8 deaths per 100,000, with Black populations highest and Asian populations lowest across most detailed causes.

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Transcatheter mitral valve replacement with the SAPIEN M3 system in ENCIRCLE’s high-risk symptomatic mitral regurgitation cohort sustained MR ≤1+ in 97.0% at 2 years.

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The American College of Cardiology/American Heart Association scientific statement provides clinician guidance for tactical athletes with cardiovascular disease or risk, structured into 11 topic sections.

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In a randomized trial of transfemoral TAVR in China, single-ProGlide closure was noninferior to double-ProGlide for VARC-3 access-site or access-related vascular complications (13.1% vs 15.1%).

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In ASAP-TOO, left atrial appendage closure with a Watchman device achieved 97.8% implantation success and a 1.0% primary safety event rate through 5 years in OAC-unsuitable atrial fibrillation patients.

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ARC-HBR criteria identify STEMI patients undergoing primary PCI with substantially higher 12-month risk, but do not show a more favorable effect for upfront aspirin omission.